Bone Abstracts

: Rickets can occur due to vitamin D deficiency or defects in its metabolism. Mutations in the CYP27B1 gene, which encodes vitamin D 1α-hydroxylase, are the genetic basis of vitamin D-dependent rickets type 1A (VDDR1A, OMIM 264700). Vitamin D dependent rickets type 1 is inherited in an autosomal recessive pattern. We report here a new mutation in CYP27B1, which lead to vitamin D dependent rickets type 1. Two boy siblings from a consanguineous Turkish family presented to e...

Pamidronate, used for the treatment of paediatric osteoporosis, reduces the fracture rate and improves ambulatory status. Pamidronate is a potent inhibitor drug of bone resorption. After i.v. administration, the drug is extensively taken up in bone, where it binds with hydroxyapatite crystals in the bone matrix. Matrix-bound pamidronate inhibits osteoclast activity. Pamidronate is well tolerated by most patients.We report a patient who developed venous t...

Periodontitis is a health condition that involves inflammation of the periodontium, the supporting tissues, bones and ligaments around the teeth. In severe cases, the alveolar bone in the jaw area can become degraded and, without treatment, eventually lead to the loss of teeth. Periodontitis is the primary cause of tooth loss in adults. Regeneration of these tissues has become the most vital aim of periodontal surgery. For this situation, bone greft, syntetic materials and gro...

Pathologist Christian Georg Schmorl described a specific type of vertebral lesion, which is now known as Schmorl’s node. A Schmorl’s node or intradiscal herniation is herniation of nucleus pulposus through the cartilaginous and bony end plate into the body of an adjacent vertebra. Schmorl nodes are seen primarily in the thoracolumbar spines in an elderly population. Schmorl nodes are associated with moderate but not advanced degenerative changes. An 11-year-male pres...